Mostafa Sadeghi; AliReza Saliminai; Ali movafegh
Volume 17, Issue 1 , March and April 2010, , Pages 13-20
Abstract
Background and Purpose: Use of intrathecal opioids causes an increase in the block depth of anesthetics and duration of analgesia. Intrathecal opioids are associated with side effects such as itching, nausea and vomiting. However, the use of NSAIDs reduces itching induced by intrathecal opioids. Therefore, ...
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Background and Purpose: Use of intrathecal opioids causes an increase in the block depth of anesthetics and duration of analgesia. Intrathecal opioids are associated with side effects such as itching, nausea and vomiting. However, the use of NSAIDs reduces itching induced by intrathecal opioids. Therefore, the present study intends to determine and compare the effects of nanogram celecoxib on reducing the incidence and intensity of intrathecal meperidine-induced pruritus. Methods and Materials: This double-blind clinical trial was conducted on 90 patients undergoing caesarean section. Patients were randomly assigned into experimental and control groups. The experimental group received 25ng/kg or 100ng/kg celecoxib and the control group received oral placebo. Patients under spinal anesthesia received meperidine 10mg with intrathecal Bupivacaine 0.5%. Then, pruritus was assessed 0, 2, 6, 12 and 24 hours after surgery, and were recorded by scoring criteria. The obtained data were analyzed in SPSS using one-way ANOVA, chi-square and Fisher’s exact test. Values below 5% were considered significant. Results: The difference of the two groups in their age, weight and oral intake was not significant (confidence interval 95%). The incidence of itching in the experimental groups of 25ng/kg (p=0.049) or 100ng/kg celecoxib (p=0.001) in 0 and 2 hours after surgery were significantly lower than the control group; also, the intensity of itching 2 hours after surgery was significantly lower then the control group (p=0.001). Conclusion: Nanogram doses of Celecoxib can be used for reducing the incidence and intensity of meperidine induced pruritus.
Mohammadesmail Darabi; Kamran Yazarloo; Seyyed Mohammad Mireskanadari; Mostafa Sadeghi
Volume 16, Issue 2 , July and August 2009, , Pages 87-93
Abstract
Background and Purpose: As postoperative pain is inappropriately controlled in children and because narcotics are not used in children because of respiratory complications an appropriate analgesic with fewer side effects is essential. The aim of this study has been to investigate the effect of rectal ...
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Background and Purpose: As postoperative pain is inappropriately controlled in children and because narcotics are not used in children because of respiratory complications an appropriate analgesic with fewer side effects is essential. The aim of this study has been to investigate the effect of rectal diclofenac and acetaminophen or their combination on postoperative pain in children undergoing cleft palate repair. Methods and Materials: This double blind randomized clinical trial was conducted on 87 children undergoing cleft palate repair surgery. After obtaining informed consent they were randomly assigned into one of the three groups: rectal diclofenac (Group D) and acetaminophen (Group A) or their combination (Group A+D). Postoperative pain was measured and recorded 1 2 6 12 24 36 and 48 hours after surgery using CHOPES scale. For data analysis Smearnoff-Kolmogroff chi-square Fischer's exact test ANOVA and Kruskal-Wallis tests were used in SPSS. Results: According to the findings patients in Group D showed lower pain score (6.38±0.89) as compared with Group A (6.83±1.32) and Group A+D (6.5±1.12); also Group D had less opioid requirements (3 cases in Group D 26 in Group A and 24 cases in Group A+D). Patients in Group D were significantly different from those in the other two groups as for the time of first required dose of opioid in the postoperative period; mean for Group D was 2:55 hours after surgery (SD=2:44) group A 00:88 hours (SD=00:48) and Group A+D 00:85 hours (SD=1:12). Conclusion: The present research suggests that rectal diclofenac (as compared with acetaminophen or a combination of both) is a more effective medication for postoperative pain alleviation in children undergoing cleft palate repair surgery.